Self-reported loss of smell without nasal obstruction to identify COVID-19. The multicenter Coranosmia cohort study.
Identifieur interne : 000639 ( Main/Exploration ); précédent : 000638; suivant : 000640Self-reported loss of smell without nasal obstruction to identify COVID-19. The multicenter Coranosmia cohort study.
Auteurs : Dominique Salmon Ceron [France] ; Sophie Bartier [France] ; Charlotte Hautefort [France] ; Yann Nguyen [France] ; Jérôme Nevoux [France] ; Anne-Laure Hamel [France] ; Yohan Camhi [France] ; Florence Canouï-Poitrine [France] ; Benjamin Verillaud [France] ; Dorsaf Slama [France] ; Stephanie Haim-Boukobza [France] ; Elise Sourdeau [France] ; Delphine Cantin [France] ; Alain Corré [France] ; Agnes Bryn [France] ; Nicolas Etienne [France] ; Flore Rozenberg [France] ; Richard Layese [France] ; Jean-François Papon [France] ; Emilie Bequignon [France]Source :
- The Journal of infection [ 1532-2742 ] ; 2020.
Abstract
OBJECTIVES
To determine the frequency of SARS-CoV-2 positive samples in a subset of patients consulting for primarily isolated acute (<7 days) loss of smell and to assess the diagnostic accuracy of olfactory/gustatory dysfunction for COVID-19 diagnosis in the overall population tested for COVID-19 in the same period.
METHODS
Prospective multicentric cohort study in four olfactory ENT units and a screening center for COVID-19.
RESULTS
i) Among a subset of 55 patients consulting for primarily recent loss of smell, we found that 51 (92.7%) had a COVID-19 positive test (median viral load of 28.8 cycle threshold). Loss of smell was mostly total (anosmia), rarely associated with nasal obstruction but associated with a taste disorder in 80%. Olfactory dysfunction occurred suddenly, either as first complaint or preceded by mild symptoms occurring a median of 3 days. The majority of patients (72.9%) partially recovered the sense of smell within 15 days. ii) In a population of 1824 patients tested for COVID-19, the positive predictive value and the specificity of loss of smell and/or taste were 78.5% and 90.3% respectively (sensitivity (40.8%), negative predictive value (63.6%)).
CONCLUSIONS
Self-reported loss of smell had a high predictive positive value to identify COVID-19. Making this sign well known publicly could help to adopt isolation measures and inform potential contacts.
DOI: 10.1016/j.jinf.2020.07.005
PubMed: 32650110
PubMed Central: PMC7338860
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Self-reported loss of smell without nasal obstruction to identify COVID-19. The multicenter Coranosmia cohort study.</title><author><name sortKey="Salmon Ceron, Dominique" sort="Salmon Ceron, Dominique" uniqKey="Salmon Ceron D" first="Dominique" last="Salmon Ceron">Dominique Salmon Ceron</name><affiliation wicri:level="3"><nlm:affiliation>Department of Infectious Diseases and Immunology, Hotel Dieu Hospital, Paris Public Hospitals (APHP), 1 Place du Parvis de Notre-Dame, Paris 75004, France; University of Paris, School of Medicine, Paris 75005, France. Electronic address: dominique.salmon@aphp.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Infectious Diseases and Immunology, Hotel Dieu Hospital, Paris Public Hospitals (APHP), 1 Place du Parvis de Notre-Dame, Paris 75004, France; University of Paris, School of Medicine, Paris 75005</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Bartier, Sophie" sort="Bartier, Sophie" uniqKey="Bartier S" first="Sophie" last="Bartier">Sophie Bartier</name><affiliation wicri:level="3"><nlm:affiliation>Department of Oto-rhino-laryngology, Head and Neck Surgery, Intercommunal Hospital of Créteil, Créteil 94000, France; University Paris-Est Créteil (UPEC), School of Medicine, Créteil 94000, France; INSERM U955, IMRB- CEpiA team, 94000 Créteil, France Paris Public Hospitals Henri Mondor Hospital (APHP), Créteil 94000, France; Department of Oto-rhino-laryngology, Henri Mondor Hospital of Créteil, Paris Public Hospitals, Créteil 94000, France; Centre National de la Recherche Scientifique CNRS, ERL 7000, Créteil 94000, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Oto-rhino-laryngology, Head and Neck Surgery, Intercommunal Hospital of Créteil, Créteil 94000, France; University Paris-Est Créteil (UPEC), School of Medicine, Créteil 94000, France; INSERM U955, IMRB- CEpiA team, 94000 Créteil, France Paris Public Hospitals Henri Mondor Hospital (APHP), Créteil 94000, France; Department of Oto-rhino-laryngology, Henri Mondor Hospital of Créteil, Paris Public Hospitals, Créteil 94000, France; Centre National de la Recherche Scientifique CNRS, ERL 7000, Créteil 94000</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Hautefort, Charlotte" sort="Hautefort, Charlotte" uniqKey="Hautefort C" first="Charlotte" last="Hautefort">Charlotte Hautefort</name><affiliation wicri:level="3"><nlm:affiliation>Department of Oto-rhino-laryngology Head and Neck Surgery, Paris Public Hospitals, Lariboisière Hospital (APHP), Paris 75010, France; University Paris Diderot, School of Medicine, Paris 75010, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Oto-rhino-laryngology Head and Neck Surgery, Paris Public Hospitals, Lariboisière Hospital (APHP), Paris 75010, France; University Paris Diderot, School of Medicine, Paris 75010</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Nguyen, Yann" sort="Nguyen, Yann" uniqKey="Nguyen Y" first="Yann" last="Nguyen">Yann Nguyen</name><affiliation wicri:level="3"><nlm:affiliation>Department of Oto-rhino-laryngology Head and Neck Surgery, Paris Public Hospitals, AP-HP Sorbonne University Hospital Pitié Salpêtrière Hospital (AP-HP), Paris 75006, France; Sorbonne University, Paris 75013, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Oto-rhino-laryngology Head and Neck Surgery, Paris Public Hospitals, AP-HP Sorbonne University Hospital Pitié Salpêtrière Hospital (AP-HP), Paris 75006, France; Sorbonne University, Paris 75013</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Nevoux, Jerome" sort="Nevoux, Jerome" uniqKey="Nevoux J" first="Jérôme" last="Nevoux">Jérôme Nevoux</name><affiliation wicri:level="3"><nlm:affiliation>Groupe Hospitalier Paris-Saclay, Hôpital Bicêtre, Department of Oto-rhino-laryngology Head and Neck Surgery, Paris Public Hospitals. Le Kremlin-Bicêtre 94270, France; Université Paris-Saclay, Faculté de Médecine, Le Kremlin-Bicêtre F-94275, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Groupe Hospitalier Paris-Saclay, Hôpital Bicêtre, Department of Oto-rhino-laryngology Head and Neck Surgery, Paris Public Hospitals. Le Kremlin-Bicêtre 94270, France; Université Paris-Saclay, Faculté de Médecine, Le Kremlin-Bicêtre F-94275</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Hamel, Anne Laure" sort="Hamel, Anne Laure" uniqKey="Hamel A" first="Anne-Laure" last="Hamel">Anne-Laure Hamel</name><affiliation wicri:level="3"><nlm:affiliation>Department of Oto-rhino-laryngology Head and Neck Surgery, Paris Public Hospitals, Lariboisière Hospital (APHP), Paris 75010, France; University Paris Diderot, School of Medicine, Paris 75010, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Oto-rhino-laryngology Head and Neck Surgery, Paris Public Hospitals, Lariboisière Hospital (APHP), Paris 75010, France; University Paris Diderot, School of Medicine, Paris 75010</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Camhi, Yohan" sort="Camhi, Yohan" uniqKey="Camhi Y" first="Yohan" last="Camhi">Yohan Camhi</name><affiliation wicri:level="3"><nlm:affiliation>Department of Oto-rhino-laryngology Head and Neck Surgery, Paris Public Hospitals, AP-HP Sorbonne University Hospital Pitié Salpêtrière Hospital (AP-HP), Paris 75006, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Oto-rhino-laryngology Head and Neck Surgery, Paris Public Hospitals, AP-HP Sorbonne University Hospital Pitié Salpêtrière Hospital (AP-HP), Paris 75006</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Canoui Poitrine, Florence" sort="Canoui Poitrine, Florence" uniqKey="Canoui Poitrine F" first="Florence" last="Canouï-Poitrine">Florence Canouï-Poitrine</name><affiliation wicri:level="3"><nlm:affiliation>University Paris-Est Créteil (UPEC), School of Medicine, Créteil 94000, France; INSERM U955, IMRB- CEpiA team, 94000 Créteil, France Paris Public Hospitals Henri Mondor Hospital (APHP), Créteil 94000, France; Clinical Research Unit: (URC-Mondor), Department of Public Health, Henri Mondor Hospital Paris Public Hospitals (AP-HP), Créteil 94000, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University Paris-Est Créteil (UPEC), School of Medicine, Créteil 94000, France; INSERM U955, IMRB- CEpiA team, 94000 Créteil, France Paris Public Hospitals Henri Mondor Hospital (APHP), Créteil 94000, France; Clinical Research Unit: (URC-Mondor), Department of Public Health, Henri Mondor Hospital Paris Public Hospitals (AP-HP), Créteil 94000</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Verillaud, Benjamin" sort="Verillaud, Benjamin" uniqKey="Verillaud B" first="Benjamin" last="Verillaud">Benjamin Verillaud</name><affiliation wicri:level="3"><nlm:affiliation>Department of Oto-rhino-laryngology Head and Neck Surgery, Paris Public Hospitals, Lariboisière Hospital (APHP), Paris 75010, France; University Paris Diderot, School of Medicine, Paris 75010, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Oto-rhino-laryngology Head and Neck Surgery, Paris Public Hospitals, Lariboisière Hospital (APHP), Paris 75010, France; University Paris Diderot, School of Medicine, Paris 75010</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Slama, Dorsaf" sort="Slama, Dorsaf" uniqKey="Slama D" first="Dorsaf" last="Slama">Dorsaf Slama</name><affiliation wicri:level="3"><nlm:affiliation>Department of Infectious Diseases and Immunology, Hotel Dieu Hospital, Paris Public Hospitals (APHP), 1 Place du Parvis de Notre-Dame, Paris 75004, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Infectious Diseases and Immunology, Hotel Dieu Hospital, Paris Public Hospitals (APHP), 1 Place du Parvis de Notre-Dame, Paris 75004</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Haim Boukobza, Stephanie" sort="Haim Boukobza, Stephanie" uniqKey="Haim Boukobza S" first="Stephanie" last="Haim-Boukobza">Stephanie Haim-Boukobza</name><affiliation wicri:level="1"><nlm:affiliation>Cerba Laboratory, Saint-Ouen L'Aumône, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Cerba Laboratory, Saint-Ouen L'Aumône</wicri:regionArea><wicri:noRegion>Saint-Ouen L'Aumône</wicri:noRegion><wicri:noRegion>Saint-Ouen L'Aumône</wicri:noRegion></affiliation></author><author><name sortKey="Sourdeau, Elise" sort="Sourdeau, Elise" uniqKey="Sourdeau E" first="Elise" last="Sourdeau">Elise Sourdeau</name><affiliation wicri:level="3"><nlm:affiliation>Emergency Department, Hotel Dieu Hospital, Paris Public Hospitals (APHP), Paris 75004, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Emergency Department, Hotel Dieu Hospital, Paris Public Hospitals (APHP), Paris 75004</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Cantin, Delphine" sort="Cantin, Delphine" uniqKey="Cantin D" first="Delphine" last="Cantin">Delphine Cantin</name><affiliation wicri:level="3"><nlm:affiliation>Emergency Department, Hotel Dieu Hospital, Paris Public Hospitals (APHP), Paris 75004, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Emergency Department, Hotel Dieu Hospital, Paris Public Hospitals (APHP), Paris 75004</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Corre, Alain" sort="Corre, Alain" uniqKey="Corre A" first="Alain" last="Corré">Alain Corré</name><affiliation wicri:level="3"><nlm:affiliation>Department of Oto-rhino-laryngology Head and Neck Surgery, Hopital Rothschild Foundation, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Oto-rhino-laryngology Head and Neck Surgery, Hopital Rothschild Foundation, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bryn, Agnes" sort="Bryn, Agnes" uniqKey="Bryn A" first="Agnes" last="Bryn">Agnes Bryn</name><affiliation wicri:level="3"><nlm:affiliation>University of Paris, School of Medicine, Paris 75005, France; General Medical Practioner, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Paris, School of Medicine, Paris 75005, France; General Medical Practioner, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Etienne, Nicolas" sort="Etienne, Nicolas" uniqKey="Etienne N" first="Nicolas" last="Etienne">Nicolas Etienne</name><affiliation wicri:level="3"><nlm:affiliation>Department of Infectious Diseases and Immunology, Hotel Dieu Hospital, Paris Public Hospitals (APHP), 1 Place du Parvis de Notre-Dame, Paris 75004, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Infectious Diseases and Immunology, Hotel Dieu Hospital, Paris Public Hospitals (APHP), 1 Place du Parvis de Notre-Dame, Paris 75004</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Rozenberg, Flore" sort="Rozenberg, Flore" uniqKey="Rozenberg F" first="Flore" last="Rozenberg">Flore Rozenberg</name><affiliation wicri:level="3"><nlm:affiliation>University of Paris, School of Medicine, Paris 75005, France; Virology Department, Cochin Hospital, Paris Public Hospitals (APHP), Paris 75004, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Paris, School of Medicine, Paris 75005, France; Virology Department, Cochin Hospital, Paris Public Hospitals (APHP), Paris 75004</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Layese, Richard" sort="Layese, Richard" uniqKey="Layese R" first="Richard" last="Layese">Richard Layese</name><affiliation wicri:level="3"><nlm:affiliation>University Paris-Est Créteil (UPEC), School of Medicine, Créteil 94000, France; INSERM U955, IMRB- CEpiA team, 94000 Créteil, France Paris Public Hospitals Henri Mondor Hospital (APHP), Créteil 94000, France; Clinical Research Unit: (URC-Mondor), Department of Public Health, Henri Mondor Hospital Paris Public Hospitals (AP-HP), Créteil 94000, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University Paris-Est Créteil (UPEC), School of Medicine, Créteil 94000, France; INSERM U955, IMRB- CEpiA team, 94000 Créteil, France Paris Public Hospitals Henri Mondor Hospital (APHP), Créteil 94000, France; Clinical Research Unit: (URC-Mondor), Department of Public Health, Henri Mondor Hospital Paris Public Hospitals (AP-HP), Créteil 94000</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Papon, Jean Francois" sort="Papon, Jean Francois" uniqKey="Papon J" first="Jean-François" last="Papon">Jean-François Papon</name><affiliation wicri:level="3"><nlm:affiliation>INSERM U955, IMRB- CEpiA team, 94000 Créteil, France Paris Public Hospitals Henri Mondor Hospital (APHP), Créteil 94000, France; Centre National de la Recherche Scientifique CNRS, ERL 7000, Créteil 94000, France; Groupe Hospitalier Paris-Saclay, Hôpital Bicêtre, Department of Oto-rhino-laryngology Head and Neck Surgery, Paris Public Hospitals. Le Kremlin-Bicêtre 94270, France; Université Paris-Saclay, Faculté de Médecine, Le Kremlin-Bicêtre F-94275, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U955, IMRB- CEpiA team, 94000 Créteil, France Paris Public Hospitals Henri Mondor Hospital (APHP), Créteil 94000, France; Centre National de la Recherche Scientifique CNRS, ERL 7000, Créteil 94000, France; Groupe Hospitalier Paris-Saclay, Hôpital Bicêtre, Department of Oto-rhino-laryngology Head and Neck Surgery, Paris Public Hospitals. Le Kremlin-Bicêtre 94270, France; Université Paris-Saclay, Faculté de Médecine, Le Kremlin-Bicêtre F-94275</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Bequignon, Emilie" sort="Bequignon, Emilie" uniqKey="Bequignon E" first="Emilie" last="Bequignon">Emilie Bequignon</name><affiliation wicri:level="3"><nlm:affiliation>Department of Oto-rhino-laryngology, Head and Neck Surgery, Intercommunal Hospital of Créteil, Créteil 94000, France; University Paris-Est Créteil (UPEC), School of Medicine, Créteil 94000, France; INSERM U955, IMRB- CEpiA team, 94000 Créteil, France Paris Public Hospitals Henri Mondor Hospital (APHP), Créteil 94000, France; Department of Oto-rhino-laryngology, Henri Mondor Hospital of Créteil, Paris Public Hospitals, Créteil 94000, France; Centre National de la Recherche Scientifique CNRS, ERL 7000, Créteil 94000, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Oto-rhino-laryngology, Head and Neck Surgery, Intercommunal Hospital of Créteil, Créteil 94000, France; University Paris-Est Créteil (UPEC), School of Medicine, Créteil 94000, France; INSERM U955, IMRB- CEpiA team, 94000 Créteil, France Paris Public Hospitals Henri Mondor Hospital (APHP), Créteil 94000, France; Department of Oto-rhino-laryngology, Henri Mondor Hospital of Créteil, Paris Public Hospitals, Créteil 94000, France; Centre National de la Recherche Scientifique CNRS, ERL 7000, Créteil 94000</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32650110</idno><idno type="pmid">32650110</idno><idno type="doi">10.1016/j.jinf.2020.07.005</idno><idno type="pmc">PMC7338860</idno><idno type="wicri:Area/Main/Corpus">000A28</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000A28</idno><idno type="wicri:Area/Main/Curation">000A28</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000A28</idno><idno type="wicri:Area/Main/Exploration">000A28</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Self-reported loss of smell without nasal obstruction to identify COVID-19. The multicenter Coranosmia cohort study.</title><author><name sortKey="Salmon Ceron, Dominique" sort="Salmon Ceron, Dominique" uniqKey="Salmon Ceron D" first="Dominique" last="Salmon Ceron">Dominique Salmon Ceron</name><affiliation wicri:level="3"><nlm:affiliation>Department of Infectious Diseases and Immunology, Hotel Dieu Hospital, Paris Public Hospitals (APHP), 1 Place du Parvis de Notre-Dame, Paris 75004, France; University of Paris, School of Medicine, Paris 75005, France. Electronic address: dominique.salmon@aphp.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Infectious Diseases and Immunology, Hotel Dieu Hospital, Paris Public Hospitals (APHP), 1 Place du Parvis de Notre-Dame, Paris 75004, France; University of Paris, School of Medicine, Paris 75005</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Bartier, Sophie" sort="Bartier, Sophie" uniqKey="Bartier S" first="Sophie" last="Bartier">Sophie Bartier</name><affiliation wicri:level="3"><nlm:affiliation>Department of Oto-rhino-laryngology, Head and Neck Surgery, Intercommunal Hospital of Créteil, Créteil 94000, France; University Paris-Est Créteil (UPEC), School of Medicine, Créteil 94000, France; INSERM U955, IMRB- CEpiA team, 94000 Créteil, France Paris Public Hospitals Henri Mondor Hospital (APHP), Créteil 94000, France; Department of Oto-rhino-laryngology, Henri Mondor Hospital of Créteil, Paris Public Hospitals, Créteil 94000, France; Centre National de la Recherche Scientifique CNRS, ERL 7000, Créteil 94000, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Oto-rhino-laryngology, Head and Neck Surgery, Intercommunal Hospital of Créteil, Créteil 94000, France; University Paris-Est Créteil (UPEC), School of Medicine, Créteil 94000, France; INSERM U955, IMRB- CEpiA team, 94000 Créteil, France Paris Public Hospitals Henri Mondor Hospital (APHP), Créteil 94000, France; Department of Oto-rhino-laryngology, Henri Mondor Hospital of Créteil, Paris Public Hospitals, Créteil 94000, France; Centre National de la Recherche Scientifique CNRS, ERL 7000, Créteil 94000</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Hautefort, Charlotte" sort="Hautefort, Charlotte" uniqKey="Hautefort C" first="Charlotte" last="Hautefort">Charlotte Hautefort</name><affiliation wicri:level="3"><nlm:affiliation>Department of Oto-rhino-laryngology Head and Neck Surgery, Paris Public Hospitals, Lariboisière Hospital (APHP), Paris 75010, France; University Paris Diderot, School of Medicine, Paris 75010, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Oto-rhino-laryngology Head and Neck Surgery, Paris Public Hospitals, Lariboisière Hospital (APHP), Paris 75010, France; University Paris Diderot, School of Medicine, Paris 75010</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Nguyen, Yann" sort="Nguyen, Yann" uniqKey="Nguyen Y" first="Yann" last="Nguyen">Yann Nguyen</name><affiliation wicri:level="3"><nlm:affiliation>Department of Oto-rhino-laryngology Head and Neck Surgery, Paris Public Hospitals, AP-HP Sorbonne University Hospital Pitié Salpêtrière Hospital (AP-HP), Paris 75006, France; Sorbonne University, Paris 75013, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Oto-rhino-laryngology Head and Neck Surgery, Paris Public Hospitals, AP-HP Sorbonne University Hospital Pitié Salpêtrière Hospital (AP-HP), Paris 75006, France; Sorbonne University, Paris 75013</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Nevoux, Jerome" sort="Nevoux, Jerome" uniqKey="Nevoux J" first="Jérôme" last="Nevoux">Jérôme Nevoux</name><affiliation wicri:level="3"><nlm:affiliation>Groupe Hospitalier Paris-Saclay, Hôpital Bicêtre, Department of Oto-rhino-laryngology Head and Neck Surgery, Paris Public Hospitals. Le Kremlin-Bicêtre 94270, France; Université Paris-Saclay, Faculté de Médecine, Le Kremlin-Bicêtre F-94275, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Groupe Hospitalier Paris-Saclay, Hôpital Bicêtre, Department of Oto-rhino-laryngology Head and Neck Surgery, Paris Public Hospitals. Le Kremlin-Bicêtre 94270, France; Université Paris-Saclay, Faculté de Médecine, Le Kremlin-Bicêtre F-94275</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Hamel, Anne Laure" sort="Hamel, Anne Laure" uniqKey="Hamel A" first="Anne-Laure" last="Hamel">Anne-Laure Hamel</name><affiliation wicri:level="3"><nlm:affiliation>Department of Oto-rhino-laryngology Head and Neck Surgery, Paris Public Hospitals, Lariboisière Hospital (APHP), Paris 75010, France; University Paris Diderot, School of Medicine, Paris 75010, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Oto-rhino-laryngology Head and Neck Surgery, Paris Public Hospitals, Lariboisière Hospital (APHP), Paris 75010, France; University Paris Diderot, School of Medicine, Paris 75010</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Camhi, Yohan" sort="Camhi, Yohan" uniqKey="Camhi Y" first="Yohan" last="Camhi">Yohan Camhi</name><affiliation wicri:level="3"><nlm:affiliation>Department of Oto-rhino-laryngology Head and Neck Surgery, Paris Public Hospitals, AP-HP Sorbonne University Hospital Pitié Salpêtrière Hospital (AP-HP), Paris 75006, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Oto-rhino-laryngology Head and Neck Surgery, Paris Public Hospitals, AP-HP Sorbonne University Hospital Pitié Salpêtrière Hospital (AP-HP), Paris 75006</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Canoui Poitrine, Florence" sort="Canoui Poitrine, Florence" uniqKey="Canoui Poitrine F" first="Florence" last="Canouï-Poitrine">Florence Canouï-Poitrine</name><affiliation wicri:level="3"><nlm:affiliation>University Paris-Est Créteil (UPEC), School of Medicine, Créteil 94000, France; INSERM U955, IMRB- CEpiA team, 94000 Créteil, France Paris Public Hospitals Henri Mondor Hospital (APHP), Créteil 94000, France; Clinical Research Unit: (URC-Mondor), Department of Public Health, Henri Mondor Hospital Paris Public Hospitals (AP-HP), Créteil 94000, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University Paris-Est Créteil (UPEC), School of Medicine, Créteil 94000, France; INSERM U955, IMRB- CEpiA team, 94000 Créteil, France Paris Public Hospitals Henri Mondor Hospital (APHP), Créteil 94000, France; Clinical Research Unit: (URC-Mondor), Department of Public Health, Henri Mondor Hospital Paris Public Hospitals (AP-HP), Créteil 94000</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Verillaud, Benjamin" sort="Verillaud, Benjamin" uniqKey="Verillaud B" first="Benjamin" last="Verillaud">Benjamin Verillaud</name><affiliation wicri:level="3"><nlm:affiliation>Department of Oto-rhino-laryngology Head and Neck Surgery, Paris Public Hospitals, Lariboisière Hospital (APHP), Paris 75010, France; University Paris Diderot, School of Medicine, Paris 75010, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Oto-rhino-laryngology Head and Neck Surgery, Paris Public Hospitals, Lariboisière Hospital (APHP), Paris 75010, France; University Paris Diderot, School of Medicine, Paris 75010</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Slama, Dorsaf" sort="Slama, Dorsaf" uniqKey="Slama D" first="Dorsaf" last="Slama">Dorsaf Slama</name><affiliation wicri:level="3"><nlm:affiliation>Department of Infectious Diseases and Immunology, Hotel Dieu Hospital, Paris Public Hospitals (APHP), 1 Place du Parvis de Notre-Dame, Paris 75004, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Infectious Diseases and Immunology, Hotel Dieu Hospital, Paris Public Hospitals (APHP), 1 Place du Parvis de Notre-Dame, Paris 75004</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Haim Boukobza, Stephanie" sort="Haim Boukobza, Stephanie" uniqKey="Haim Boukobza S" first="Stephanie" last="Haim-Boukobza">Stephanie Haim-Boukobza</name><affiliation wicri:level="1"><nlm:affiliation>Cerba Laboratory, Saint-Ouen L'Aumône, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Cerba Laboratory, Saint-Ouen L'Aumône</wicri:regionArea><wicri:noRegion>Saint-Ouen L'Aumône</wicri:noRegion><wicri:noRegion>Saint-Ouen L'Aumône</wicri:noRegion></affiliation></author><author><name sortKey="Sourdeau, Elise" sort="Sourdeau, Elise" uniqKey="Sourdeau E" first="Elise" last="Sourdeau">Elise Sourdeau</name><affiliation wicri:level="3"><nlm:affiliation>Emergency Department, Hotel Dieu Hospital, Paris Public Hospitals (APHP), Paris 75004, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Emergency Department, Hotel Dieu Hospital, Paris Public Hospitals (APHP), Paris 75004</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Cantin, Delphine" sort="Cantin, Delphine" uniqKey="Cantin D" first="Delphine" last="Cantin">Delphine Cantin</name><affiliation wicri:level="3"><nlm:affiliation>Emergency Department, Hotel Dieu Hospital, Paris Public Hospitals (APHP), Paris 75004, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Emergency Department, Hotel Dieu Hospital, Paris Public Hospitals (APHP), Paris 75004</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Corre, Alain" sort="Corre, Alain" uniqKey="Corre A" first="Alain" last="Corré">Alain Corré</name><affiliation wicri:level="3"><nlm:affiliation>Department of Oto-rhino-laryngology Head and Neck Surgery, Hopital Rothschild Foundation, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Oto-rhino-laryngology Head and Neck Surgery, Hopital Rothschild Foundation, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bryn, Agnes" sort="Bryn, Agnes" uniqKey="Bryn A" first="Agnes" last="Bryn">Agnes Bryn</name><affiliation wicri:level="3"><nlm:affiliation>University of Paris, School of Medicine, Paris 75005, France; General Medical Practioner, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Paris, School of Medicine, Paris 75005, France; General Medical Practioner, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Etienne, Nicolas" sort="Etienne, Nicolas" uniqKey="Etienne N" first="Nicolas" last="Etienne">Nicolas Etienne</name><affiliation wicri:level="3"><nlm:affiliation>Department of Infectious Diseases and Immunology, Hotel Dieu Hospital, Paris Public Hospitals (APHP), 1 Place du Parvis de Notre-Dame, Paris 75004, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Infectious Diseases and Immunology, Hotel Dieu Hospital, Paris Public Hospitals (APHP), 1 Place du Parvis de Notre-Dame, Paris 75004</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Rozenberg, Flore" sort="Rozenberg, Flore" uniqKey="Rozenberg F" first="Flore" last="Rozenberg">Flore Rozenberg</name><affiliation wicri:level="3"><nlm:affiliation>University of Paris, School of Medicine, Paris 75005, France; Virology Department, Cochin Hospital, Paris Public Hospitals (APHP), Paris 75004, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Paris, School of Medicine, Paris 75005, France; Virology Department, Cochin Hospital, Paris Public Hospitals (APHP), Paris 75004</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Layese, Richard" sort="Layese, Richard" uniqKey="Layese R" first="Richard" last="Layese">Richard Layese</name><affiliation wicri:level="3"><nlm:affiliation>University Paris-Est Créteil (UPEC), School of Medicine, Créteil 94000, France; INSERM U955, IMRB- CEpiA team, 94000 Créteil, France Paris Public Hospitals Henri Mondor Hospital (APHP), Créteil 94000, France; Clinical Research Unit: (URC-Mondor), Department of Public Health, Henri Mondor Hospital Paris Public Hospitals (AP-HP), Créteil 94000, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University Paris-Est Créteil (UPEC), School of Medicine, Créteil 94000, France; INSERM U955, IMRB- CEpiA team, 94000 Créteil, France Paris Public Hospitals Henri Mondor Hospital (APHP), Créteil 94000, France; Clinical Research Unit: (URC-Mondor), Department of Public Health, Henri Mondor Hospital Paris Public Hospitals (AP-HP), Créteil 94000</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Papon, Jean Francois" sort="Papon, Jean Francois" uniqKey="Papon J" first="Jean-François" last="Papon">Jean-François Papon</name><affiliation wicri:level="3"><nlm:affiliation>INSERM U955, IMRB- CEpiA team, 94000 Créteil, France Paris Public Hospitals Henri Mondor Hospital (APHP), Créteil 94000, France; Centre National de la Recherche Scientifique CNRS, ERL 7000, Créteil 94000, France; Groupe Hospitalier Paris-Saclay, Hôpital Bicêtre, Department of Oto-rhino-laryngology Head and Neck Surgery, Paris Public Hospitals. Le Kremlin-Bicêtre 94270, France; Université Paris-Saclay, Faculté de Médecine, Le Kremlin-Bicêtre F-94275, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U955, IMRB- CEpiA team, 94000 Créteil, France Paris Public Hospitals Henri Mondor Hospital (APHP), Créteil 94000, France; Centre National de la Recherche Scientifique CNRS, ERL 7000, Créteil 94000, France; Groupe Hospitalier Paris-Saclay, Hôpital Bicêtre, Department of Oto-rhino-laryngology Head and Neck Surgery, Paris Public Hospitals. Le Kremlin-Bicêtre 94270, France; Université Paris-Saclay, Faculté de Médecine, Le Kremlin-Bicêtre F-94275</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Bequignon, Emilie" sort="Bequignon, Emilie" uniqKey="Bequignon E" first="Emilie" last="Bequignon">Emilie Bequignon</name><affiliation wicri:level="3"><nlm:affiliation>Department of Oto-rhino-laryngology, Head and Neck Surgery, Intercommunal Hospital of Créteil, Créteil 94000, France; University Paris-Est Créteil (UPEC), School of Medicine, Créteil 94000, France; INSERM U955, IMRB- CEpiA team, 94000 Créteil, France Paris Public Hospitals Henri Mondor Hospital (APHP), Créteil 94000, France; Department of Oto-rhino-laryngology, Henri Mondor Hospital of Créteil, Paris Public Hospitals, Créteil 94000, France; Centre National de la Recherche Scientifique CNRS, ERL 7000, Créteil 94000, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Oto-rhino-laryngology, Head and Neck Surgery, Intercommunal Hospital of Créteil, Créteil 94000, France; University Paris-Est Créteil (UPEC), School of Medicine, Créteil 94000, France; INSERM U955, IMRB- CEpiA team, 94000 Créteil, France Paris Public Hospitals Henri Mondor Hospital (APHP), Créteil 94000, France; Department of Oto-rhino-laryngology, Henri Mondor Hospital of Créteil, Paris Public Hospitals, Créteil 94000, France; Centre National de la Recherche Scientifique CNRS, ERL 7000, Créteil 94000</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author></analytic><series><title level="j">The Journal of infection</title><idno type="eISSN">1532-2742</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b></p><p>To determine the frequency of SARS-CoV-2 positive samples in a subset of patients consulting for primarily isolated acute (<7 days) loss of smell and to assess the diagnostic accuracy of olfactory/gustatory dysfunction for COVID-19 diagnosis in the overall population tested for COVID-19 in the same period.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Prospective multicentric cohort study in four olfactory ENT units and a screening center for COVID-19.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>i) Among a subset of 55 patients consulting for primarily recent loss of smell, we found that 51 (92.7%) had a COVID-19 positive test (median viral load of 28.8 cycle threshold). Loss of smell was mostly total (anosmia), rarely associated with nasal obstruction but associated with a taste disorder in 80%. Olfactory dysfunction occurred suddenly, either as first complaint or preceded by mild symptoms occurring a median of 3 days. The majority of patients (72.9%) partially recovered the sense of smell within 15 days. ii) In a population of 1824 patients tested for COVID-19, the positive predictive value and the specificity of loss of smell and/or taste were 78.5% and 90.3% respectively (sensitivity (40.8%), negative predictive value (63.6%)).</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Self-reported loss of smell had a high predictive positive value to identify COVID-19. Making this sign well known publicly could help to adopt isolation measures and inform potential contacts.</p></div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">32650110</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1532-2742</ISSN><JournalIssue CitedMedium="Internet"><Volume>81</Volume><Issue>4</Issue><PubDate><Year>2020</Year><Month>Oct</Month></PubDate></JournalIssue><Title>The Journal of infection</Title><ISOAbbreviation>J. Infect.</ISOAbbreviation></Journal><ArticleTitle>Self-reported loss of smell without nasal obstruction to identify COVID-19. The multicenter Coranosmia cohort study.</ArticleTitle><Pagination><MedlinePgn>614-620</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0163-4453(20)30463-1</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jinf.2020.07.005</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To determine the frequency of SARS-CoV-2 positive samples in a subset of patients consulting for primarily isolated acute (<7 days) loss of smell and to assess the diagnostic accuracy of olfactory/gustatory dysfunction for COVID-19 diagnosis in the overall population tested for COVID-19 in the same period.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Prospective multicentric cohort study in four olfactory ENT units and a screening center for COVID-19.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">i) Among a subset of 55 patients consulting for primarily recent loss of smell, we found that 51 (92.7%) had a COVID-19 positive test (median viral load of 28.8 cycle threshold). Loss of smell was mostly total (anosmia), rarely associated with nasal obstruction but associated with a taste disorder in 80%. Olfactory dysfunction occurred suddenly, either as first complaint or preceded by mild symptoms occurring a median of 3 days. The majority of patients (72.9%) partially recovered the sense of smell within 15 days. ii) In a population of 1824 patients tested for COVID-19, the positive predictive value and the specificity of loss of smell and/or taste were 78.5% and 90.3% respectively (sensitivity (40.8%), negative predictive value (63.6%)).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Self-reported loss of smell had a high predictive positive value to identify COVID-19. Making this sign well known publicly could help to adopt isolation measures and inform potential contacts.</AbstractText><CopyrightInformation>Copyright © 2020. Published by Elsevier Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Salmon Ceron</LastName><ForeName>Dominique</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Infectious Diseases and Immunology, Hotel Dieu Hospital, Paris Public Hospitals (APHP), 1 Place du Parvis de Notre-Dame, Paris 75004, France; University of Paris, School of Medicine, Paris 75005, France. Electronic address: dominique.salmon@aphp.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bartier</LastName><ForeName>Sophie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Oto-rhino-laryngology, Head and Neck Surgery, Intercommunal Hospital of Créteil, Créteil 94000, France; University Paris-Est Créteil (UPEC), School of Medicine, Créteil 94000, France; INSERM U955, IMRB- CEpiA team, 94000 Créteil, France Paris Public Hospitals Henri Mondor Hospital (APHP), Créteil 94000, France; Department of Oto-rhino-laryngology, Henri Mondor Hospital of Créteil, Paris Public Hospitals, Créteil 94000, France; Centre National de la Recherche Scientifique CNRS, ERL 7000, Créteil 94000, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hautefort</LastName><ForeName>Charlotte</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Oto-rhino-laryngology Head and Neck Surgery, Paris Public Hospitals, Lariboisière Hospital (APHP), Paris 75010, France; University Paris Diderot, School of Medicine, Paris 75010, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nguyen</LastName><ForeName>Yann</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Oto-rhino-laryngology Head and Neck Surgery, Paris Public Hospitals, AP-HP Sorbonne University Hospital Pitié Salpêtrière Hospital (AP-HP), Paris 75006, France; Sorbonne University, Paris 75013, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nevoux</LastName><ForeName>Jérôme</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Groupe Hospitalier Paris-Saclay, Hôpital Bicêtre, Department of Oto-rhino-laryngology Head and Neck Surgery, Paris Public Hospitals. Le Kremlin-Bicêtre 94270, France; Université Paris-Saclay, Faculté de Médecine, Le Kremlin-Bicêtre F-94275, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hamel</LastName><ForeName>Anne-Laure</ForeName><Initials>AL</Initials><AffiliationInfo><Affiliation>Department of Oto-rhino-laryngology Head and Neck Surgery, Paris Public Hospitals, Lariboisière Hospital (APHP), Paris 75010, France; University Paris Diderot, School of Medicine, Paris 75010, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Camhi</LastName><ForeName>Yohan</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Oto-rhino-laryngology Head and Neck Surgery, Paris Public Hospitals, AP-HP Sorbonne University Hospital Pitié Salpêtrière Hospital (AP-HP), Paris 75006, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Canouï-Poitrine</LastName><ForeName>Florence</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>University Paris-Est Créteil (UPEC), School of Medicine, Créteil 94000, France; INSERM U955, IMRB- CEpiA team, 94000 Créteil, France Paris Public Hospitals Henri Mondor Hospital (APHP), Créteil 94000, France; Clinical Research Unit: (URC-Mondor), Department of Public Health, Henri Mondor Hospital Paris Public Hospitals (AP-HP), Créteil 94000, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Verillaud</LastName><ForeName>Benjamin</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Oto-rhino-laryngology Head and Neck Surgery, Paris Public Hospitals, Lariboisière Hospital (APHP), Paris 75010, France; University Paris Diderot, School of Medicine, Paris 75010, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Slama</LastName><ForeName>Dorsaf</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Infectious Diseases and Immunology, Hotel Dieu Hospital, Paris Public Hospitals (APHP), 1 Place du Parvis de Notre-Dame, Paris 75004, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Haim-Boukobza</LastName><ForeName>Stephanie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Cerba Laboratory, Saint-Ouen L'Aumône, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sourdeau</LastName><ForeName>Elise</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Emergency Department, Hotel Dieu Hospital, Paris Public Hospitals (APHP), Paris 75004, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cantin</LastName><ForeName>Delphine</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Emergency Department, Hotel Dieu Hospital, Paris Public Hospitals (APHP), Paris 75004, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Corré</LastName><ForeName>Alain</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Oto-rhino-laryngology Head and Neck Surgery, Hopital Rothschild Foundation, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bryn</LastName><ForeName>Agnes</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>University of Paris, School of Medicine, Paris 75005, France; General Medical Practioner, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Etienne</LastName><ForeName>Nicolas</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Infectious Diseases and Immunology, Hotel Dieu Hospital, Paris Public Hospitals (APHP), 1 Place du Parvis de Notre-Dame, Paris 75004, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rozenberg</LastName><ForeName>Flore</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>University of Paris, School of Medicine, Paris 75005, France; Virology Department, Cochin Hospital, Paris Public Hospitals (APHP), Paris 75004, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Layese</LastName><ForeName>Richard</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>University Paris-Est Créteil (UPEC), School of Medicine, Créteil 94000, France; INSERM U955, IMRB- CEpiA team, 94000 Créteil, France Paris Public Hospitals Henri Mondor Hospital (APHP), Créteil 94000, France; Clinical Research Unit: (URC-Mondor), Department of Public Health, Henri Mondor Hospital Paris Public Hospitals (AP-HP), Créteil 94000, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Papon</LastName><ForeName>Jean-François</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>INSERM U955, IMRB- CEpiA team, 94000 Créteil, France Paris Public Hospitals Henri Mondor Hospital (APHP), Créteil 94000, France; Centre National de la Recherche Scientifique CNRS, ERL 7000, Créteil 94000, France; Groupe Hospitalier Paris-Saclay, Hôpital Bicêtre, Department of Oto-rhino-laryngology Head and Neck Surgery, Paris Public Hospitals. Le Kremlin-Bicêtre 94270, France; Université Paris-Saclay, Faculté de Médecine, Le Kremlin-Bicêtre F-94275, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bequignon</LastName><ForeName>Emilie</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Oto-rhino-laryngology, Head and Neck Surgery, Intercommunal Hospital of Créteil, Créteil 94000, France; University Paris-Est Créteil (UPEC), School of Medicine, Créteil 94000, France; INSERM U955, IMRB- CEpiA team, 94000 Créteil, France Paris Public Hospitals Henri Mondor Hospital (APHP), Créteil 94000, France; Department of Oto-rhino-laryngology, Henri Mondor Hospital of Créteil, Paris Public Hospitals, Créteil 94000, France; Centre National de la Recherche Scientifique CNRS, ERL 7000, Créteil 94000, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>APHP COVID-19 research collaboration</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>07</Month><Day>07</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Infect</MedlineTA><NlmUniqueID>7908424</NlmUniqueID><ISSNLinking>0163-4453</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Anosmia</Keyword><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">Dysguageusia</Keyword><Keyword MajorTopicYN="N">Loss of smell</Keyword><Keyword MajorTopicYN="N">Positive predictive value</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword><Keyword MajorTopicYN="N">Viral load</Keyword></KeywordList><CoiStatement>Declaration of Competing Interest All the authors have read and agreed with the paper's content. No authors have financial or personal conflicts. Neither the work nor any part of its essential substance, tables or figures have been or will be published or submitted to another scientific journal or are being considered for publication elsewhere.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>05</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>07</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>07</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>7</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>7</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>7</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32650110</ArticleId><ArticleId IdType="pii">S0163-4453(20)30463-1</ArticleId><ArticleId IdType="doi">10.1016/j.jinf.2020.07.005</ArticleId><ArticleId IdType="pmc">PMC7338860</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Salmon Ceron, Dominique" sort="Salmon Ceron, Dominique" uniqKey="Salmon Ceron D" first="Dominique" last="Salmon Ceron">Dominique Salmon Ceron</name></region><name sortKey="Bartier, Sophie" sort="Bartier, Sophie" uniqKey="Bartier S" first="Sophie" last="Bartier">Sophie Bartier</name><name sortKey="Bequignon, Emilie" sort="Bequignon, Emilie" uniqKey="Bequignon E" first="Emilie" last="Bequignon">Emilie Bequignon</name><name sortKey="Bryn, Agnes" sort="Bryn, Agnes" uniqKey="Bryn A" first="Agnes" last="Bryn">Agnes Bryn</name><name sortKey="Camhi, Yohan" sort="Camhi, Yohan" uniqKey="Camhi Y" first="Yohan" last="Camhi">Yohan Camhi</name><name sortKey="Canoui Poitrine, Florence" sort="Canoui Poitrine, Florence" uniqKey="Canoui Poitrine F" first="Florence" last="Canouï-Poitrine">Florence Canouï-Poitrine</name><name sortKey="Cantin, Delphine" sort="Cantin, Delphine" uniqKey="Cantin D" first="Delphine" last="Cantin">Delphine Cantin</name><name sortKey="Corre, Alain" sort="Corre, Alain" uniqKey="Corre A" first="Alain" last="Corré">Alain Corré</name><name sortKey="Etienne, Nicolas" sort="Etienne, Nicolas" uniqKey="Etienne N" first="Nicolas" last="Etienne">Nicolas Etienne</name><name sortKey="Haim Boukobza, Stephanie" sort="Haim Boukobza, Stephanie" uniqKey="Haim Boukobza S" first="Stephanie" last="Haim-Boukobza">Stephanie Haim-Boukobza</name><name sortKey="Hamel, Anne Laure" sort="Hamel, Anne Laure" uniqKey="Hamel A" first="Anne-Laure" last="Hamel">Anne-Laure Hamel</name><name sortKey="Hautefort, Charlotte" sort="Hautefort, Charlotte" uniqKey="Hautefort C" first="Charlotte" last="Hautefort">Charlotte Hautefort</name><name sortKey="Layese, Richard" sort="Layese, Richard" uniqKey="Layese R" first="Richard" last="Layese">Richard Layese</name><name sortKey="Nevoux, Jerome" sort="Nevoux, Jerome" uniqKey="Nevoux J" first="Jérôme" last="Nevoux">Jérôme Nevoux</name><name sortKey="Nguyen, Yann" sort="Nguyen, Yann" uniqKey="Nguyen Y" first="Yann" last="Nguyen">Yann Nguyen</name><name sortKey="Papon, Jean Francois" sort="Papon, Jean Francois" uniqKey="Papon J" first="Jean-François" last="Papon">Jean-François Papon</name><name sortKey="Rozenberg, Flore" sort="Rozenberg, Flore" uniqKey="Rozenberg F" first="Flore" last="Rozenberg">Flore Rozenberg</name><name sortKey="Slama, Dorsaf" sort="Slama, Dorsaf" uniqKey="Slama D" first="Dorsaf" last="Slama">Dorsaf Slama</name><name sortKey="Sourdeau, Elise" sort="Sourdeau, Elise" uniqKey="Sourdeau E" first="Elise" last="Sourdeau">Elise Sourdeau</name><name sortKey="Verillaud, Benjamin" sort="Verillaud, Benjamin" uniqKey="Verillaud B" first="Benjamin" last="Verillaud">Benjamin Verillaud</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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